Polγ coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity
Author:
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Structural Biology
Link
https://www.nature.com/articles/s41594-023-00980-2.pdf
Reference70 articles.
1. Robberson, D. L., Kasamatsu, H. & Vinograd, J. Replication of mitochondrial DNA. Circular replicative intermediates in mouse L cells. Proc. Natl Acad. Sci. USA 69, 737–741 (1972).
2. Berk, A. J. & Clayton, D. A. Mechanism of mitochondrial DNA replication in mouse L-cells: asynchronous replication of strands, segregation of circular daughter molecules, aspects of topology and turnover of an initiation sequence. J. Mol. Biol. 86, 801–824 (1974).
3. Lim, S. E., Longley, M. J. & Copeland, W. C. The mitochondrial p55 accessory subunit of human DNA polymerase γ enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance. J. Biol. Chem. 274, 38197–38203 (1999).
4. Yin, Y. W. Structural insight on processivity, human disease and antiviral drug toxicity. Curr. Opin. Struct. Biol. 21, 83–91 (2011).
5. Lee, Y. S., Kennedy, W. D. & Yin, Y. W. Structural insights into human mitochondrial DNA replication and disease-related polymerase mutations. Cell 139, 312–324 (2009).
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