Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules-Reference-Cited by-同舟云学术

Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules

Published:2024-01-04 Issue:2 Volume:31 Page:311-322
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Hickey Christopher M.,Digianantonio Katherine M.,Zimmermann Kurt^ORCID,Harbin Alicia,Quinn Connor,Patel Avani,Gareiss Peter^ORCID,Chapman Amanda,Tiberi Bernadette,Dobrodziej Jennifer,Corradi John,Cacace Angela M.,Langley David R.,Békés Miklós^ORCID

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41594-023-01146-w.pdf

Reference53 articles.

1. Ciechanover, A., Orian, A. & Schwartz, A. L. Ubiquitin-mediated proteolysis: biological regulation via destruction. Bioessays 22, 442–51 (2000).

2. Békés, M., Langley, D. R. & Crews, C. M. PROTAC targeted protein degraders: the past is prologue. Nat. Rev. Drug Discov. 21, 181–200 (2022).

3. Komander, D. & Rape, M. The ubiquitin code. Annu. Rev. Biochem. 81, 203–29 (2012).

4. Sakamoto, K. M. et al. Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proc. Natl Acad. Sci. USA 98, 8554–9 (2001).

5. Faust, T. B., Donovan, K. A., Yue, H., Chamberlain, P. P. & Fischer, E. S. Small-molecule approaches to targeted protein degradation. Annu. Rev. Cancer Biol. 5, 181–201 (2021).

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7;ACS Chemical Biology;2024-06-27

2. Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation;Nature Communications;2024-06-26

3. Expanding the ligand spaces for E3 ligases for the design of protein degraders;Bioorganic & Medicinal Chemistry;2024-05

4. Applications of protein ubiquitylation and deubiquitylation in drug discovery;Journal of Biological Chemistry;2024-05

5. Breaking Bad Proteins—Discovery Approaches and the Road to Clinic for Degraders;Cells;2024-03-26