RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2-Reference-Cited by-同舟云学术

RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

Published:2019-03 Issue:3 Volume:26 Page:237-247
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Zhang Qi,McKenzie Nicholas J.,Warneford-Thomson Robert^ORCID,Gail Emma H.,Flanigan Sarena F.,Owen Brady M.,Lauman Richard,Levina Vitalina,Garcia Benjamin A.,Schittenhelm Ralf B.,Bonasio Roberto^ORCID,Davidovich Chen^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/s41594-019-0197-y.pdf

Reference57 articles.

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2. Margueron, R. & Reinberg, D. The polycomb complex PRC2 and its mark in life. Nature 469, 343–349 (2011).

3. Simon, J. A. & Kingston, R. E. Occupying chromatin: polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol. Cell 49, 808–824 (2013).

4. Comet, I., Riising, E. M., Leblanc, B. & Helin, K. Maintaining cell identity: PRC2-mediated regulation of transcription and cancer. Nat. Rev. Cancer 16, 803–810 (2016).

5. Kasinath, V. et al. Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science 359, 940–944 (2018).

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