Transient protein folding in condensates reveals ways to target disordered oncoproteins
Author:
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Structural Biology
Link
https://www.nature.com/articles/s41594-023-01160-y.pdf
Reference5 articles.
1. Bradner, J. E., Hnisz, D. & Young, R. A. Transcriptional addiction in Cancer. Cell 168, 629–643 (2017). This review describes various mechanisms of transcriptional dysregulation in cancer.
2. Biesaga, M., Frigolé-Vivas, M. & Salvatella, X. Intrinsically disordered proteins and biomolecular condensates as drug targets. Curr. Opin. Chem. Biol. 62, 90–100 (2021). This review describes insights and challenges of targeting intrinsically disordered proteins with small molecules.
3. Tomura, A. et al. The subnuclear three-dimensional image analysis of androgen receptor fused to green fluorescence protein. J. Biol. Chem. 276, 28395–28401 (2001). This paper reported hormone-dependent speckle formation by the androgen receptor.
4. Andersen, R. J. et al. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell 17, 535–546 (2010). This paper reports the identification of EPI-001 from a phenotypic screen, active against castration-resistant prostate cancer.
5. De Mol, E. et al. EPI-001, a compound active against castration-resistant prostate cancer, targets Transactivation Unit 5 of the androgen receptor. ACS Chem. Biol. 11, 2499–2505 (2016). This paper reports NMR data on the binding of EPI-001 to an intrinsically disordered sub-domain of the androgen receptor.
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3