Cryo-EM structure reveals how SID-1 recognizes dsRNA that initiates systemic RNAi
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41594-024-01277-8.pdf
Reference5 articles.
1. Hannon, G. J. RNA interference. Nature 418, 244–251 (2002). A review article that presents the finding and mechanism of RNAi.
2. Winston, W. M., Molodowitch, C. & Hunter, C. P. Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1. Science 295, 2456–2459 (2002). This paper reports that SID-1 is expressed in cells sensitive to RNAi and is required for systemic RNAi.
3. Feinberg, E. H. & Hunter, C. P. Transport of dsRNA into cells by the transmembrane protein SID-1. Science 301, 1545–1547 (2003). This paper reports that SID-1 mediates dsRNA transport in S2 cells and systemic RNAi in C. elegans.
4. Zheng, L. et al. Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity. Cell Res. 34, 80–83 (2024). This article describes human SIDT1 and SIDT2 structures and low-pH-dependent RNA binding to the isolated extracellular domain of SIDT1.
5. Qian, D. et al. Structural insight into the human SID1 transmembrane family member 2 reveals its lipid hydrolytic activity. Nat. Commun. 14, 3568 (2023). This article describes ceramidase activity of human SIDT2 with the conserved Zn2+ site as the catalytic center.
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