A structurally minimized yet fully active insulin based on cone-snail venom insulin principles
Author:
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Structural Biology
Link
http://www.nature.com/articles/s41594-020-0430-8.pdf
Reference53 articles.
1. Safavi-Hemami, H. et al. Specialized insulin is used for chemical warfare by fish-hunting cone snails. Proc. Natl Acad. Sci. USA 112, 1743–1748 (2015).
2. Menting, J. G. et al. A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin. Nat. Struct. Mol. Biol. 23, 916–920 (2016).
3. Carpenter, F. H. Relationship of structure to biological activity of insulin as revealed by degradative studies. Am. J. Med. 40, 750–758 (1966).
4. Gradel, A. K. J. et al. Factors affecting the absorption of subcutaneously administered insulin: effect on variability. J. Diabetes Res. 2018, 1205121 (2018).
5. Maikawa, C. L. et al. Stable monomeric insulin formulations enabled by supramolecular pegylation of insulin analogues. Adv. Ther. 3, 1900094 (2020).
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