Magic bullets or novel multimodal drugs with various CNS targets for Parkinson's disease?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd2330.pdf
Reference12 articles.
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3. Van der Schyf, C. J., Gal, S., Geldenhuys, W. J. & Youdim, M. B. H. Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases. Expert Opin. Invest. Drugs 15, 873–886 (2006).
4. Youdim, M. B. H., Maruyama, W. & Naoi, M. Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline. Drugs Today 41, 369–391 (2005).
5. Sagi, Y., Mandel, S., Amit, T. & Youdim, M. B. Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism. Neurobiol. Dis. 25, 35–44 (2007).
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