Turn motif phosphorylation negatively regulates activation loop phosphorylation in Akt
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Molecular Biology
Link
http://www.nature.com/articles/onc2011155.pdf
Reference47 articles.
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3. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB et al. (1997b). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7: 261–269.
4. Andjelković M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA . (1996). Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA 93: 5699–5704.
5. Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N . (2002). Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 277: 39858–39866.
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