SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Molecular Biology
Link
http://www.nature.com/articles/onc201137.pdf
Reference43 articles.
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3. Bell EL, Klimova TA, Eisenbart J, Moraes CT, Murphy MP, Budinger GRS et al. (2007a). The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol 177: 1029–1036.
4. Bell EL, Klimova TA, Eisenbart J, Schumacker PT, Chandel NS . (2007b). Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia. Mol Cell Biol 27: 5737–5745.
5. Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, De Rango F et al. (2005). A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 85: 258–263.
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