Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer

Author:

Gill R K,Yang S-H,Meerzaman D,Mechanic L E,Bowman E D,Jeon H-S,Roy Chowdhuri S,Shakoori A,Dracheva T,Hong K-M,Fukuoka J,Zhang J-H,Harris C C,Jen J

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Reference44 articles.

1. Alessi DR, Sakamoto K, Bayascas JR . (2006). LKB1-dependent signaling pathways. Annu Rev Biochem 75: 137–163.

2. Avizienyte E, Loukola A, Roth S, Hemminki A, Tarkkanen M, Salovaara R et al. (1999). LKB1 somatic mutations in sporadic tumors. Am J Pathol 154: 677–681.

3. Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe RA, Stenwig AE et al. (1998). Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. Cancer Res 58: 2087–2090.

4. Bignell GR, Barfoot R, Seal S, Collins N, Warren W, Stratton MR . (1998). Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. Cancer Res 58: 1384–1386.

5. Cairns P, Polascik TJ, Eby Y, Tokino K, Califano J, Merlo A et al. (1995). Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nat Genet 11: 210–212.

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