Reconstructing organisms in silico: genome-scale models and their emerging applications
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Immunology and Microbiology,Microbiology,Infectious Diseases
Link
https://www.nature.com/articles/s41579-020-00440-4.pdf
Reference141 articles.
1. Thiele, I. & Palsson, B. Ø. A protocol for generating a high-quality genome-scale metabolic reconstruction. Nat. Protoc. 5, 93–121 (2010). A detailed protocol to reconstruct a GEM from a genome sequence.
2. Norsigian, C. J., Fang, X., Seif, Y., Monk, J. M. & Palsson, B. O. A workflow for generating multi-strain genome-scale metabolic models of prokaryotes. Nat. Protoc. 15, 1–14 (2020). This article provides a semi-automated workflow to generate strain-specific GEMs from a curated reference model.
3. Price, N. D., Reed, J. L. & Palsson, B. Ø. Genome-scale models of microbial cells: evaluating the consequences of constraints. Nat. Rev. Microbiol. 2, 886–897 (2004).
4. Lewis, N. E., Nagarajan, H. & Palsson, B. O. Constraining the metabolic genotype–phenotype relationship using a phylogeny of in silico methods. Nat. Rev. Microbiol. 10, 291–305 (2012).
5. Kanehisa, M. & Goto, S. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 28, 27–30 (2000).
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