The influence of the 'organizational factor' on compound quality in drug discovery
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd3552.pdf
Reference96 articles.
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4. Lipinski, C. A., Lombardo, F., Dominy, B. W. & Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23, 3–25 (1997).
5. Gleeson, M. P. Generation of a set of simple, interpretable ADMET rules of thumb. J. Med. Chem. 51, 817–834 (2008). Based on GlaxoSmithKline's data, the ADMET risk is shown to be reduced when molecular mass is <400 Da and cLogP is <4.
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