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Statins and cancer prevention

Published:2005-12 Issue:12 Volume:5 Page:930-942
ISSN:1474-175X
Container-title:Nature Reviews Cancer
language:en
Short-container-title:Nat Rev Cancer

Author:

Demierre Marie-France,Higgins Peter D. R.,Gruber Stephen B.,Hawk Ernest,Lippman Scott M.

Publisher

Springer Science and Business Media LLC

Subject

General Earth and Planetary Sciences,General Environmental Science

Link

http://www.nature.com/articles/nrc1751.pdf

Reference127 articles.

1. Oliver, M. F. Might treatment of hypercholesterolaemia increase non-cardiac mortality? Lancet 337, 1529–1531 (1991).

2. Newman, T. B. & Hulley, S. B. Carcinogenicity of lipid-lowering drugs. JAMA 275, 55–60 (1996).

3. Ridker, P. M. et al. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) investigators. Circulation 98, 839–844 (1998). Important early report indicating that statins can have cholesterol-independent effects — such as anti-inflammatory effects that are proving to be important in CVD, cancer and other disease settings — in addition to well-known HMG-CoA reductase-dependent and cholesterol-dependent effects.

4. Gotto, A. M. Jr et al. Relation between baseline and on-treatment lipid parameters and first acute major coronary events in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). Circulation 101, 477–484 (2000).

5. Ehrenstein, M. R., Jury, E. C. & Mauri, C. Statins for atherosclerosis — as good as it gets? N. Engl. J. Med. 352, 73–75 (2005).

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