Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

Author:

Jiang Kun,Zhong Bin,Gilvary Danielle L.,Corliss Brian C.,Hong-Geller Elizabeth,Wei Sheng,Djeu Julie Y.

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Reference32 articles.

1. Brumbaugh, K. M. et al. Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity. J. Exp. Med. 186 , 1965–1974 (1997).

2. Gismondi, A. et al. Cutting edge: functional role for proline-rich tyrosine kinase 2 in NK cell-mediated natural cytotoxicity. J. Immunol. 164, 2272–2276 (2000).

3. Palmieri, G. et al. CD94/NKG2-A inhibitory complex blocks CD16-triggered Syk and extracellular regulated kinase activation, leading to cytotoxic function of human NK cells. J. Immunol. 162, 7181– 7188 (1999).

4. Billadeau, D. D. et al. The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing. J. Exp. Med. 188 , 549–559 (1998).

5. Trotta, R. et al. Dependence of both spontaneous and antibody-dependent, granule exocytosis-mediated NK cell cytotoxicity on extracellular signal- regulated kinases. J. Immunol. 161, 6648– 6656 (1998).

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