Reduced levels of dopamine and altered metabolism in brains of HPRT knock-out rats: a new rodent model of Lesch-Nyhan Disease-Reference-Cited by-同舟云学术

Reduced levels of dopamine and altered metabolism in brains of HPRT knock-out rats: a new rodent model of Lesch-Nyhan Disease

Published:2016-05 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Meek Stephen,Thomson Alison J.,Sutherland Linda,Sharp Matthew G. F.,Thomson Julie,Bishop Valerie,Meddle Simone L.,Gloaguen Yoann,Weidt Stefan,Singh-Dolt Karamjit,Buehr Mia,Brown Helen K.,Gill Andrew C.,Burdon Tom

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep25592.pdf

Reference48 articles.

1. Lesch, M. & Nyhan, W. L. A Familial Disorder of Uric Acid Metabolism and Central Nervous System Function. Am. J. Med. 36, 561–570 (1964).

2. Yang, T. P. et al. Molecular evidence for new mutation at the hprt locus in Lesch-Nyhan patients. Nature 310, 412–414 (1984).

3. Nyhan, W. L. Dopamine function in Lesch-Nyhan disease. Environ. Health Perspect. 108 Suppl 3, 409–411 (2000).

4. Lloyd, K. G. et al. Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome. N. Engl. J. Med. 305, 1106–1111, doi: 10.1056/NEJM198111053051902 (1981).

5. Breese, G. R. et al. Neonatal-6-hydroxydopamine treatment: model of susceptibility for self-mutilation in the Lesch-Nyhan syndrome. Pharmacol. Biochem. Behav. 21, 459–461 (1984).

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