Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri2491.pdf
Reference119 articles.
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3. Nishimoto, N. et al. Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins. Proc. Natl Acad. Sci. USA 88, 6284–6288 (1991).
4. Jumaa, H., Hendriks, R. W. & Reth, M. B cell signaling and tumorigenesis. Annu. Rev. Immunol. 23, 415–445 (2005).
5. Reth, M., Petrac, E., Wiese, P., Lobel, L. & Alt, F. W. Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. EMBO J. 6, 3299–3305 (1987). This study shows that the membrane expression of Igμ by pre-B cells activates the Igκ locus, which provided the first suggestion of the sequential recombination of IgH and IgL genes and indicated that the pre-B cell-stage functions as an important checkpoint in early B-cell development.
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