Extrachromosomal DNA amplifications in cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
https://www.nature.com/articles/s41576-022-00521-5.pdf
Reference90 articles.
1. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature 578, 82–93 (2020).
2. Group, P. T. C. et al. Genomic basis for RNA alterations in cancer. Nature 578, 129–136 (2020).
3. Verhaak, R. G. W., Bafna, V. & Mischel, P. S. Extrachromosomal oncogene amplification in tumour pathogenesis and evolution. Nat. Rev. Cancer 19, 283–288 (2019).
4. deCarvalho, A. C. et al. Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma. Nat. Genet. 50, 708–717 (2018).
5. Turner, K. M. et al. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature 543, 122–125 (2017). Together with deCarvalho et al. (2018), this work demonstrates that ecDNA is highly frequently observed in brain tumours, providing early suggestions that the ecDNA incidence in cancer is much higher than previously thought.
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