Nascent RNA analyses: tracking transcription and its regulation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/s41576-019-0159-6.pdf
Reference218 articles.
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2. Long, H. K., Prescott, S. L. & Wysocka, J. Ever-changing landscapes: transcriptional enhancers in development and evolution. Cell 167, 1170–1187 (2016).
3. Zabidi, M. A. & Stark, A. Regulatory enhancer-core-promoter communication via transcription factors and cofactors. Trends Genet. 32, 801–814 (2016).
4. Core, L. J. et al. Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers. Nat. Genet. 46, 1311–1320 (2014). This study identifies the unified architecture of regulatory elements at genes and enhancers, comprising two core initiation regions to coordinate divergent transcription. It also maps enhancers across the human genome using their characteristic pattern of unstable, divergent transcription.
5. Scruggs, B. S. et al. Bidirectional transcription arises from two distinct hubs of transcription factor binding and active chromatin. Mol. Cell 58, 1101–1112 (2015).
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