Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists-Reference-Cited by-同舟云学术

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists

Published:2016-04 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Seow Vernon,Lim Junxian,Cotterell Adam J.,Yau Mei-Kwan,Xu Weijun,Lohman Rink-Jan,Kok W. Mei,Stoermer Martin J.,Sweet Matthew J.,Reid Robert C.,Suen Jacky Y.,Fairlie David P.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep24575.pdf

Reference46 articles.

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3. Veber, D. F., Johnson, S. R., Cheng, H. Y., Ward, B. R. & Kopple, K. D. Molecular properties that influences the oral bioavailability of drug candidates. J. Med. Chem. 45, 2615–2623 (2002).

4. Monk, P. N., Scola, A. M., Madala, P. & Fairlie, D. P. Function, structure and therapeutic potential of complement C5a receptors. Br. J. Pharmacol. 152, 429–448 (2007).

5. Lim, J. et al. C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. FASEB J. 27, 822–831 (2013).

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