When less is more: the PI3K pathway as a determinant of tumor response to dietary restriction
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/cr200981.pdf
Reference15 articles.
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2. Tannenbaum A, Silverstone H . The influence of the degree of caloric restriction on the formation of skin tumors and hepatomas in mice. Cancer Res 1949; 9:724–727.
3. Weindruch R, Walford R . Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 1982; 215:1415–1418.
4. Kalaany NY, Sabatini DM . Tumours with PI3K activation are resistant to dietary restriction. Nature 2009; 458:725–731.
5. Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB . Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Disc 2005; 4:988–1004.
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