M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
Author:
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Pharmacology
Link
http://www.nature.com/articles/s41386-018-0033-9.pdf
Reference46 articles.
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3. Dean B, Hopper S, Conn PJ, Scarr E. Changes in BQCA allosteric modulation of [(3)H]NMS binding to human cortex within schizophrenia and by divalent cations. Neuropsychopharmacology. 2016;41:1620–8.
4. Scarr E, Udawela M, Thomas EA, Dean B.Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor. Mol Psychiatry. 2016;23:295–303.
5. Foster DJ, Conn PJ. Allosteric modulation of GPCRs: new insights and potential utility for treatment of schizophrenia and other CNS disorders. Neuron. 2017;94:431–46.
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