Disassociating drug active ingredients from inactive: ketamine-like synaptic effects of a ketamine excipient
Author:
Funder
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health
U.S. Department of Veterans Affairs
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Pharmacology
Link
https://www.nature.com/articles/s41386-023-01675-4.pdf
Reference6 articles.
1. Pottel J, Armstrong D, Zou L, Fekete A, Huang X-P, Torosyan H, et al. The activities of drug inactive ingredients on biological targets. Science 2020;369:403–13.
2. Dai Q, Liu X, He T, Yang C, Jiang J, Fang Y, et al. Excipient of paclitaxel induces metabolic dysregulation and unfolded protein response. Iscience. 2021;24:103170.
3. Coates KM, Flood P. Ketamine and its preservative, benzethonium chloride, both inhibit human recombinant α7 and α4β2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes. Br J Pharm. 2001;134:871–79.
4. Durieux ME, Nietgen GW. Synergistic inhibition of muscarinic signaling by ketamine stereoisomers and the preservative benzethonium chloride. Anesthesiology 1997;86:1326–33.
5. Long Y, Lin Z, Xia M, Zheng W, Li Z. Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride. Toxicol Appl Pharm. 2013;267:155–66.
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