Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4-Reference-Cited by-同舟云学术

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Published:2017-12 Issue:7684 Volume:552 Page:194-199
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Skrott Zdenek,Mistrik Martin,Andersen Klaus Kaae,Friis Søren,Majera Dusana,Gursky Jan,Ozdian Tomas,Bartkova Jirina,Turi Zsofia,Moudry Pavel,Kraus Marianne,Michalova Martina,Vaclavkova Jana,Dzubak Petr,Vrobel Ivo,Pouckova Pavla,Sedlacek Jindrich,Miklovicova Andrea,Kutt Anne,Li Jing,Mattova Jana,Driessen Christoph,Dou Q. Ping,Olsen Jørgen,Hajduch Marian,Cvek Boris,Deshaies Raymond J.,Bartek Jiri

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature25016.pdf

Reference53 articles.

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3. Iljin, K. et al. High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin. Cancer Res. 15, 6070–6078 (2009)

4. Cvek, B. Nonprofit drugs as the salvation of the world’s healthcare systems: the case of Antabuse (disulfiram). Drug Discov. Today 17, 409–412 (2012)

5. Shen, M. L., Johnson, K. L., Mays, D. C., Lipsky, J. J. & Naylor, S. Determination of in vivo adducts of disulfiram with mitochondrial aldehyde dehydrogenase. Biochem. Pharmacol. 61, 537–545 (2001)

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