Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers

Author:

Logan Jessica M.,Martini Carmela,Sorvina Alexandra,Johnson Ian R. D.ORCID,Brooks Robert D.,Caruso Maria C.,Huzzell Chelsea,Moore Courtney R.,Karageorgos Litsa,Butler Lisa M.ORCID,Tewari Prerna,Prabhakaran SaritaORCID,Hickey Shane M.,Klebe Sonja,Samaratunga Hemamali,Delahunt Brett,Moretti Kim,O’Leary John J.ORCID,Brooks Douglas A.,Ung Ben S.-Y.ORCID

Abstract

AbstractThe diagnosis of prostate cancer using histopathology is reliant on the accurate interpretation of prostate tissue sections. Current standards rely on the assessment of Haematoxylin and Eosin (H&E) staining, which can be difficult to interpret and introduce inter-observer variability. Here, we present a digital pathology atlas and online resource of prostate cancer tissue micrographs for both H&E and the reinterpretation of samples using a novel set of three biomarkers as an interactive tool, where clinicians and scientists can explore high resolution histopathology from various case studies. The digital pathology prostate cancer atlas when used in conjunction with the biomarkers, will assist pathologists to accurately grade prostate cancer tissue samples.

Publisher

Springer Science and Business Media LLC

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