Abstract
AbstractSkin permeation is an essential biological property of small organic compounds our body is exposed to, such as drugs in topic formulations, cosmetics, and environmental toxins. Despite the limited availability of experimental data, there is a lack of systematic analysis and structure. We present a novel resource on skin permeation data that collects all measurements available in the literature and systematically structures experimental conditions. Besides the skin permeation value kp, it includes experimental protocols such as skin source site, skin layer used, preparation technique, storage conditions, as well as test conditions such as temperature, pH as well as the type of donor and acceptor solution. It is important to include these parameters in the assessment of the skin permeation data. In addition, we provide an analysis of physicochemical properties and chemical space coverage, laying the basis for applicability domain determination of insights drawn from the collected data points. The database is freely accessible under https://huskindb.drug-design.de or 10.7303/syn21998881.
Publisher
Springer Science and Business Media LLC
Subject
Library and Information Sciences,Statistics, Probability and Uncertainty,Computer Science Applications,Education,Information Systems,Statistics and Probability
Reference49 articles.
1. Bolzinger, M.-A., Briançon, S., Pelletier, J. & Chevalier, Y. Penetration of drugs through skin, a complex rate-controlling membrane. Curr Opin Colloid & Interface Sci 17, 156–165 (2012).
2. Overton, E. Ueber die allgemeinen osmotischen Eigenschaften der Zelle, ihre vermutlichen Ursachen und ihre Bedeutung für die. Physiologie. Vierteljahresschr D Naturforsch Ges in Zürich 44, 88–135 (1899).
3. Url, W. Charles Ernest Overton, 75 Jahre Lipoidtheorie. Verh Zool Bot Ges Wien 115, 24–33 (1976).
4. Scheuplein, R. J. Mechanism of percutaneous adsorption. I. Routes of penetration and the influence of solubility. J Invest Dermatol 45, 334–346 (1965).
5. Scheuplein, R. J., Blank, I. H., Brauner, G. J. & MacFarlane, D. J. Percutaneous absorption of steroids. J Invest Dermatol 52, 63–70 (1969).
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