A transcriptome dataset for gonadectomy-induced changes in rat spinal cord

Author:

Miller Shawn,Abrahante Juan E.ORCID,Roopra Avtar,Dougherty Brendan J.ORCID

Abstract

AbstractCirculating sex steroid hormones are critical for neural function and development of neuroplasticity in many regions of the central nervous system. In the spinal cord, our knowledge of steroid hormone influence mostly derives from mechanistic studies of pain processing in dorsal spinal cord circuits; less is known regarding hormonal influence of ventral spinal motor function. Gonadectomy (surgical removal of the testes in males and ovaries in females) rapidly and persistently reduces circulating sex steroids in both females and males, providing a means to interrogate the role of hormones on neural function. Here we provide a next-generation RNA sequencing (RNA-seq) data set to evaluate the impact of gonadectomy on the transcriptome of ventral spinal cord tissue of adult female and male rats.

Funder

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

Craig H. Neilsen Foundation

University of Minnesota Division of Physical Therapy

Publisher

Springer Science and Business Media LLC

Subject

Library and Information Sciences,Statistics, Probability and Uncertainty,Computer Science Applications,Education,Information Systems,Statistics and Probability

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