Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep04765.pdf
Reference39 articles.
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2. Belda, O. & Targett-Adams, P. Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein. Virus Res. 170, 1–14 (2012).
3. Suk-Fong Lok, A. HCV NS5A Inhibitors in Development. Clin. Liver Dis. 17, 111–121 (2013).
4. Gao, M. et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 465, 96–100 (2010).
5. Gane, E. et al. Antiviral activity, pharmacokinetics and tolerability of AZD7295, a novel NS5A inhibitor, in a placebo-controlled multiple ascending dose study in HCV genotype 1 and 3 patients. J. Hepatol. 52, S464 (2010).
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