Turning up the pace of ion channel screening in drug discovery
Author:
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Pharmacology
Link
http://www.nature.com/articles/npp2008163.pdf
Reference5 articles.
1. Dunlop J, Bowlby M, Peri R, Vasilyev D, Arias R (2008). High-throughput electrophysiology: an emerging paradigm for ion channel screening and physiology. Nat Rev Drug Discov 7: 358–368.
2. John VH, Dale TJ, Hollands EC, Chen MX, Partington L, Downie DL et al (2007). Novel 384-well population patch clamp electrophysiology assays for Ca2+-Activated K+ channels. J Biomol Screen 12: 50–60.
3. Lu Q, An WF (2008). Impact of novel screening technologies on ion channel drug discovery. Comb Chem High Throughput Screen 11: 185–194.
4. Overington JP, Al-Lazikani B, Hopkins AL (2006). How many drug targets are there? Nat Rev Drug Discov 5: 993–996.
5. Schroeder K, Neagle B, Trezise DJ, Worley J (2003). Ionworks HT: a new high-throughput electrophysiology measurement platform. J Biomol Screen 8: 50–64.
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