From rapid In Vitro screening to rapid In Vivo screening in the drug discovery process
Author:
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Pharmacology
Link
http://www.nature.com/articles/npp2008160.pdf
Reference6 articles.
1. Dooley CT, Ny P, Bidlack JM, Houghten RA (1998). Selective ligands for the μ, δ, and κ opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library. J Biol Chem 273: 18848–18856.
2. Houghten RA (1994). Soluble combinatorial libraries: extending the range and repetoire of chemical diversity. Methods Companion Methods Enzymol 6: 354–360.
3. Houghten RA, Dooley CT, Appel JR (2006). In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands. AAPS J 8: E371–E382.
4. Houghten RA, Pinilla C, Giulianotti MA, Appel JR, Dooley CT, Nefzi A et al (2008). Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods. J Comb Chem 10: 3–19.
5. Liu B, Chang J, Gordon WP, Isbell J, Zhou Y, Tuntland T (2008). Snapshot pk: a rapid rodent in vivo preclinical screening approach. Drug Discov Today 13: 360–361.
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