Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4-Reference-Cited by-同舟云学术

Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

Published:2017-08-14 Issue:9 Volume:23 Page:1063-1071
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Dai Xiangpeng,Gan Wenjian,Li Xiaoning,Wang Shangqian,Zhang Wei,Huang Ling,Liu Shengwu,Zhong Qing^ORCID,Guo Jianping,Zhang Jinfang,Chen Ting,Shimizu Kouhei,Beca Francisco^ORCID,Blattner Mirjam,Vasudevan Divya,Buckley Dennis L,Qi Jun,Buser Lorenz,Liu Pengda,Inuzuka Hiroyuki,Beck Andrew H,Wang Liewei,Wild Peter J,Garraway Levi A,Rubin Mark A^ORCID,Barbieri Christopher E^ORCID,Wong Kwok-Kin,Muthuswamy Senthil K,Huang Jiaoti,Chen Yu,Bradner James E^ORCID,Wei Wenyi^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.4378.pdf

Reference41 articles.

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2. Wu, S.Y. & Chiang, C.M. The double bromodomain–containing chromatin adaptor Brd4 and transcriptional regulation. J. Biol. Chem. 282, 13141–13145 (2007).

3. Filippakopoulos, P. & Knapp, S. The bromodomain interaction module. FEBS Lett. 586, 2692–2704 (2012).

4. Filippakopoulos, P. & Knapp, S. Targeting bromodomains: epigenetic readers of lysine acetylation. Nat. Rev. Drug Discov. 13, 337–356 (2014).

5. Belkina, A.C. & Denis, G.V. BET domain co-regulators in obesity, inflammation and cancer. Nat. Rev. Cancer 12, 465–477 (2012).

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