Novel Liver-targeted conjugates of Glycogen Phosphorylase Inhibitor PSN-357 for the Treatment of Diabetes: Design, Synthesis, Pharmacokinetic and Pharmacological Evaluations-Reference-Cited by-同舟云学术

Novel Liver-targeted conjugates of Glycogen Phosphorylase Inhibitor PSN-357 for the Treatment of Diabetes: Design, Synthesis, Pharmacokinetic and Pharmacological Evaluations

Published:2017-02-22 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Zhang Liying,Song Chengjun,Miao Guangxin,Zhao Lianzhi,Yan Zhiwei,Li Jing,Wang Youde

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep42251.pdf

Reference21 articles.

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2. Newgard, C. B., Hwang, P. K. & Fletterick, R. J. The family of glycogen phosphorylases: Structure and function. Crit. Rev. Biochem. Mol. Biol. 24, 69–99 (1989).

3. Rath, V. L. et al. Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core. Mol. Cell. 6, 139–148 (2000).

4. Loughlin, W. A. Recent Advances in the Allosteric Inhibition of Glycogen Phosphorylase. Mini-Rev. Med. Chem. 10, 1139–1155 (2010). (b) Donnier-Marechal, M.; Vidal, S. Glycogen phosphorylase inhibitors: a patent review (2013–2015). Expert. Opin. Ther. Pat. 26, 199–212 (2016).

5. Baker, D. J., Greenhaff, P. L. & Timmons, J. A. Glycogen phosphorylase inhibition as a therapeutic target: a review of the recent patent literature. Expert. Opin. Ther. Pat. 16, 459–466 (2006).

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