Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing

Author:

Wiewrodt Rainer,Amin Kunjlata,Kiefer Michael,Jovanovic Vuk P,Kapoor Veena,Force Seth,Chang Michael,Lanuti Michael,Black Margaret E,Kaiser Larry R,Albelda Steven M

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Molecular Biology,Molecular Medicine

Reference38 articles.

1. Moolten FL . Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res. 1986;46:5276–5281.

2. Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM . In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science. 1992; 256:1550–1552.

3. Freeman SM, Abboud CN, Whartenby KA, Packman CH, Koeplin DS, Moolten FL, et al. The ‘bystander effect’: tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 1993;53:5274–5283.

4. Albelda SM, Wiewrodt R, Zuckerman JB . Gene therapy for lung disease: hype or hope? Ann Intern Med. 2000;132:649–660.

5. Smythe WR, Kaiser LR, Hwang HC, Amin KM, Pilewski JM, Eck SJ, et al. Successful adenovirus-mediated gene transfer in an in vivo model of human malignant mesothelioma. Ann Thorac Surg. 1994;57:1395–1401.

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