Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy

Author:

Heideman Daniëlle A M,Overmeer Renée M,van Beusechem Victor W,Lamers Wouter H,Hakvoort Theodorus B M,Snijders Peter J F,Craanen Mikael E,Offerhaus G Johan A,Meijer Chris J L M,Gerritsen Winald R

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Molecular Biology,Molecular Medicine

Reference46 articles.

1. Curley SA, Jones DV . Management of hepatocellular carcinoma. In: Meyers MA ed. Neoplasms of the digestive tract: imaging, staging and management. 1st edn. Philadelphia: Lippincott-Raven; 1998: 93–109.

2. Prieto J, Herraiz M, Sangro B, et al. The promise of gene therapy in gastrointestinal and liver diseases. Gut. 2003;52 (Suppl 2):49–54.

3. Date K, Matsumoto K, Shimura H, et al. HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor. FEBS Lett. 1997;420:1–6.

4. Kuba K, Matsumoto K, Date K, et al. HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice. Cancer Res. 2000;60:6737–6743.

5. Date K, Matsumoto K, Kuba K, et al. Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor. Oncogene. 1998;17:3045–3054.

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