Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy

Author:

Barresi Vincenza,Belluardo Natale,Sipione Simonetta,Mudó Giuseppa,Cattaneo Elena,Condorelli Daniele Filippo

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Molecular Biology,Molecular Medicine

Reference21 articles.

1. Aghi M, Hochberg F, Breakefield XO . Prodrug activation enzymes in cancer gene therapy. J Gene Med. 2000;2:148–164.

2. Austin EA, Huber BE . A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing, and expression of Escherichia coli cytosine deaminase. Mol Pharmacol. 1993;43:380–387.

3. Polak A, Scholer HJ . Mode of action of 5-fluorocytosine and mechanisms of resistance. Chemotherapy. 1975;21:113–130.

4. Mullen CA, Kilstrup M, Blaese RM . Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc Natl Acad Sci USA. 1992;89:33–37.

5. Freeman SM, Abboud CN, Whartenby KA, et al. The ‘bystander effect’: tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 1993;53:5274–5283.

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