A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein

Author:

Tychopoulos Marina,Corcos Laurent,Genne Philippe,Beaune Philippe,de Waziers Isabelle

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Molecular Biology,Molecular Medicine

Reference48 articles.

1. Springer CJ, Niculescu-Duvaz I . Approaches to gene-directed enzyme prodrug therapy (GDEPT). Adv Exp Med Biol. 2000;465:403–409.

2. Kan O, Kingsman S, Naylor S . Cytochrome P450-based cancer gene therapy: current status. Expert Opin Biol Ther. 2002;2:857–868.

3. Chen L, Waxman DJ . Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy. Cancer Res. 1995;55:581–589.

4. Code EL, Crespi CL, Penman BW, et al. Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation. Drug Metab Dispos. 1997;25:985–993.

5. Gervot L, Rochat B, Gautier JC, et al. Human CYP2B6: expression, inducibility and catalytic activities. Pharmacogenetics. 1999;9:295–306.

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