Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg.2016.28.pdf
Reference95 articles.
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5. Rouet, P., Smih, F. & Jasin, M. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol. Cell. Biol. 14, 8096–8106 (1994). This study first demonstrated that nuclease-induced DSBs could stimulate homologous recombination.
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