Ethical perspectives on pharmacogenomic profiling in the drug development process
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd771.pdf
Reference70 articles.
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2. Rioux, P. P. Clinical trials in pharmacogenetics and pharmacogenomics: methods and applications. Am. J. Health Syst. Pharm. 57, 887–898 (2000).
3. McLeod, H. L. & Evans, W. E. Pharmacogenomics: unlocking the human genome for better drug therapy. Annu. Rev. Pharmacol. Toxicol. 41, 101–121 (2001).
4. Norton, R. M. Clinical pharmacogenomics: applications in pharmaceutical R & D. Drug Discov. Today 6, 180–185 (2001).This paper provides a good overview of the types of pharmacogenomics trial that are underway at present, and why the industry might view pharmacogenomics as a potentially powerful tool in its armament.
5. Classen, D. C., Pestotnik, S. L., Evans, R. S. & Lloyd, J. F. Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. JAMA 277, 301–306 (1997).
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