Structural insights into the activation of neurokinin 2 receptor by neurokinin A
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Genetics,Molecular Biology,Biochemistry
Link
https://www.nature.com/articles/s41421-022-00437-8.pdf
Reference11 articles.
1. Steinhoff, M. S. et al. Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol. Rev. 94, 265–301 (2014).
2. Valant, C. et al. Allosteric functional switch of neurokinin A-mediated signaling at the neurokinin NK2 receptor: structural exploration. J. Med. Chem. 52, 5999–6011 (2009).
3. Lecci, A., Capriati, A. & Maggi, C. A. Tachykinin NK2 receptor antagonists for the treatment of irritable bowel syndrome. Br. J. Pharm. 141, 1249–1263 (2004).
4. Chandrashekaran, I. R., Rao, G. S. & Cowsik, S. M. Molecular modeling of the peptide agonist-binding site in a neurokinin-2 receptor. J. Chem. Inf. Model. 49, 1734–1740 (2009).
5. Muñoz, M. & Coveñas, R. Neurokinin receptor antagonism: a patent review (2014-present). Expert Opin. Ther. Pat. 30, 527–539 (2020).
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