COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan
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Published:2022-12-09
Issue:1
Volume:8
Page:
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ISSN:2056-5968
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Container-title:Cell Discovery
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language:en
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Short-container-title:Cell Discov
Author:
Liang Hong, Nian Xuanxuan, Wu JunzhengORCID, Liu Dong, Feng Lu, Lu Jia, Peng Yan, Zhou Zhijun, Deng Tao, Liu Jing, Ji Deming, Qiu Ran, Lin Lianzhen, Zeng Yan, Xia Fei, Hu Yong, Li Taojing, Duan Kai, Li Xinguo, Wang Zejun, Zhang Yong, Zhang Hang, Zhu Chen, Wang Shang, Wu Xiao, Wang Xiang, Li Yuwei, Huang Shihe, Mao Min, Guo Huanhuan, Yang Yunkai, Jia Rui, Xufang Jingwei, Wang Xuewei, Liang Shuyan, Qiu Zhixin, Zhang Juan, Ding Yaling, Li Chunyan, Zhang Jin, Fu Daoxing, He Yanlin, Zhou Dongbo, Li Cesheng, Zhang Jiayou, Yu Ding, Yang Xiao-MingORCID
Abstract
AbstractThe immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. Nevertheless, the antibody response decreased over time, and the Omicron variant exhibited more pronounced resistance to neutralization than the prototype and Delta strains. Moreover, the intensity of the SARS-CoV-2-specific CD4+ T cell response was also increased in recovered patients who received COVID-19 vaccines. Overall, the repeated antigen exposure provided by inactivated COVID-19 vaccination greatly boosted both the potency and breadth of the humoral and cellular immune responses against SARS-CoV-2, effectively protecting recovered individuals from reinfection by circulating SARS-CoV-2 and its variants.
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Genetics,Molecular Biology,Biochemistry
Reference62 articles.
1. Dong, E., Du, H. & Gardner, L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect. Dis. 20, 533–534 (2020). 2. Ai, J. et al. Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2, and BA.3 sub-lineages. Cell Host Microbe 30, 1077–1083.e4 (2022). 3. Pulliam, J. R. C. et al. Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa. Science 376, eabn4947 (2021). 4. Dan, J. M. et al. Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Science 371, eabf4063 (2021). 5. Wajnberg, A. et al. Robust neutralizing antibodies to SARS-CoV-2 infection persist for months. Science 370, 1227–1230 (2020).
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