SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2

Author:

Mu Jingfang,Fang Yaohui,Yang Qi,Shu Ting,Wang An,Huang Muhan,Jin Liang,Deng Fei,Qiu Yang,Zhou XiORCID

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry

Reference5 articles.

1. WHO. Coronavirus disease (COVID-19) Weekly Epidemiological Update. Coronavirus disease (COVID-2019) situation reports. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200824-weekly-epi-update.pdf?sfvrsn=806986d1_4. (2020).

2. Platanias, L. C. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat. Rev. Immunol. 5, 375–386 (2005).

3. Hu, Y. et al. The Severe Acute Respiratory Syndrome Coronavirus nucleocapsid inhibits type I interferon production by interfering with TRIM25-mediated RIG-I Ubiquitination. J. Virol. 91, e02143–16 (2017).

4. McBride, R., Zyl, M. & Fielding, B. The coronavirus nucleocapsid is a multifunctional protein. Viruses 6, 2991–3018 (2014).

5. Mu, J. et al. SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells. Sci China Life Sci. 63, 1–4 (2020).

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