Alkanols inhibit voltage-gated K+ channels via a distinct gating modifying mechanism that prevents gate opening
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep17402.pdf
Reference49 articles.
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3. Franks, N. P. & Lieb, W. R. What is the molecular nature of general anaesthetic target sites? Trends Pharmacol Sci 8, 169–174 (1987).
4. Covarrubias, M., Vyas, T. B., Escobar, L. & Wei, A. Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia. J Biol Chem 270, 19408–19416 (1995).
5. Long, S. B., Tao, X., Campbell, E. B. & MacKinnon, R. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature 450, 376–382 (2007).
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2. Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K+ pore;Toxicon;2016-09
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