Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion-Reference-Cited by-同舟云学术

Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion

Published:2016-11-29 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Garnett James Peter,Kalsi Kameljit K.,Sobotta Mirko,Bearham Jade,Carr Georgina,Powell Jason,Brodlie Malcolm,Ward Christopher,Tarran Robert,Baines Deborah L.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep37955.pdf

Reference29 articles.

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2. Pezzulo, A. A. et al. Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature. 487, 109–113 (2012).

3. Garland, A. L. et al. Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proc. Natl. Acad. Sci. USA 110, 15973–15978 (2013).

4. Tang, A. C. et al. Current concepts: host-pathogen interactions in cystic fibrosis airways disease. Eur. Respir. Rev. 23, 320–332 (2014).

5. Merlo, C. A. et al. Incidence and risk factors for multiple antibiotic-resistant Pseudomonas aeruginosa in cystic fibrosis. Chest. 132, 562–568 (2007).

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