Superior outcome of upfront allogeneic hematopoietic cell transplantation versus hypomethylating agent induction in myelodysplastic syndrome

Author:

Schroeder Jan ChristianORCID,Mix LucasORCID,Faustmann Philipp,Weller Jan Frederic,Fehn Adrian,Phely Laurent,Riedel Andreas,Vogel Wichard,Faul Christoph,Lengerke ClaudiaORCID,Bethge Wolfgang AndreasORCID

Publisher

Springer Science and Business Media LLC

Reference12 articles.

1. de Witte T, Bowen D, Robin M, Malcovati L, Niederwieser D, Yakoub-Agha I, et al. Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel. Blood. 2017;129:1753–62. https://doi.org/10.1182/blood-2016-06-724500

2. Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, et al. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022;140:1345–77. https://doi.org/10.1182/blood.2022016867

3. Knipp S, Hildebrand B, Kündgen A, Giagounidis A, Kobbe G, Haas R, et al. Intensive chemotherapy is not recommended for patients aged >60 years who have myelodysplastic syndromes or acute myeloid leukemia with high-risk karyotypes. Cancer. 2007;110:345–52. https://doi.org/10.1002/cncr.22779

4. Saure C, Schroeder T, Zohren F, Groten A, Bruns I, Czibere A, et al. Upfront allogeneic blood stem cell transplantation for patients with high-risk myelodysplastic syndrome or secondary acute myeloid leukemia using a FLAMSA-based high-dose sequential conditioning regimen. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 2012;18:466–72. https://doi.org/10.1016/j.bbmt.2011.09.006

5. Platzbecker U, Schetelig J, Finke J, Trenschel R, Scott BL, Kobbe G, et al. Allogeneic hematopoietic cell transplantation in patients age 60-70 years with de novo high-risk myelodysplastic syndrome or secondary acute myelogenous leukemia: comparison with patients lacking donors who received azacitidine. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 2012;18:1415–21. https://doi.org/10.1016/j.bbmt.2012.05.003

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