A prospective phase 2 clinical trial of a C5a complement inhibitor for acute GVHD with lower GI tract involvement

Author:

Mehta Rohtesh S.ORCID,Ali HarisORCID,Dai Yang,Yao Bert,Overman Bethany,Ratanatharathorn Voravit,Gill Saar,Socié GerardORCID,Anderson Kevin,Cahn Jean Yves,Mujeebuddin Arshad,Champlin RichardORCID,Shpall Elizabeth,Holtan Shernan G.,Alousi AminORCID

Funder

Alexion Pharmaceuticals

Publisher

Springer Science and Business Media LLC

Subject

Transplantation,Hematology

Reference60 articles.

1. Martin PJ, McDonald GB, Sanders JE, Anasetti C, Appelbaum FR, Deeg HJ, et al. Increasingly frequent diagnosis of acute gastrointestinal graft-versus-host disease after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transpl. 2004;10:320–7.

2. Nash RA, Antin JH, Karanes C, Fay JW, Avalos BR, Yeager AM, et al. Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. Blood. 2000;96:2062–8.

3. Ratanatharathorn V, Nash RA, Przepiorka D, Devine SM, Klein JL, Weisdorf D, et al. Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation. Blood. 1998;92:2303–14.

4. McDonald GB. How I treat acute graft-versus-host disease of the gastrointestinal tract and the liver. Blood. 2016;127:1544–50.

5. Antin JH, Chen AR, Couriel DR, Ho VT, Nash RA, Weisdorf D. Novel approaches to the therapy of steroid-resistant acute graft-versus-host disease. Biol Blood Marrow Transpl. 2004;10:655–68.

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