Impact of SARS-CoV-2 vaccination and passive prophylaxis with tixagevimab/cilgavimab on CAR-T patients: a three-year regional experience from the Italian covid pandemic

Author:

Galli EugenioORCID,Di Rocco Alice,Pansini Ilaria,Frondizi Federico,Di Palma Martina,Metafuni ElisabettaORCID,Piccirillo NicolaORCID,Bianchi Maria,Cingolani Antonella,Torelli Giovanni Fernando,Hohaus Stefan,Chiusolo PatriziaORCID,Iori Anna Paola,Sica SimonaORCID,Martelli Maurizio,Sorà FedericaORCID

Publisher

Springer Science and Business Media LLC

Subject

Transplantation,Hematology

Reference8 articles.

1. Buske C, Dreyling M, Alvarez-Larrán A, Apperley J, Arcaini L, Besson C, et al. Managing hematological cancer patients during the COVID-19 pandemic: an ESMO-EHA Interdisciplinary Expert Consensus. ESMO Open. 2022;7:100403. https://doi.org/10.1016/J.ESMOOP.2022.100403

2. Pagano L, Salmanton-García J, Marchesi F, Blennow O, Gomes da Silva M, Glenthøj A, et al. Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from EPICOVIDEHA survey. Blood. 2022;140:2773–87. https://doi.org/10.1182/blood.2022017257

3. Spanjaart AM, Ljungman P, de La Camara R, Tridello G, Ortiz-Maldonado V, Urbano-Ispizua A, et al. Poor outcome of patients with COVID-19 after CAR T-cell therapy for B-cell malignancies: results of a multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party and the European Hematology Association (EHA) Lymphoma Group. Leukemia. 2021;35:3585–8.

4. Lemoine J, Bachy E, Cartron G, Beauvais D, Gastinne T, Rubio MT, et al. Causes and risk factors of early and late non-relapse mortality after CD19 CAR T-cell therapy for diffuse large B-cell lymphoma (DLBCL): a Lysa Study from the Descar-T Registry. Blood. 2022;140:1859–61.

5. Agenzia Italiana del Farmaco Determina 15 febbraio 2022 Definizione delle modalita’ e delle condizioni di impiego dell’associazione di anticorpi monoclonali Evusheld (AZD7442; tixagevimab-cilgavimab) ai sensi del decreto 20 gennaio 2022. (Determina n. DG/87/2022) (22A01225). https://www.aifa.gov.it/registri-e-piani-terapeutici1. Accessed 25 Jan 2023.

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