Hypophosphatemia and pre-infusion thrombocytopenia as biomarkers for CRS and ICANS after CAR T therapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Transplantation,Hematology
Link
https://www.nature.com/articles/s41409-023-02083-4.pdf
Reference7 articles.
1. Hay KA, Hanafi LA, Li D, Gust J, Liles CW, Wurfel MM, et al. Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy. Blood. 2017;130:2295.
2. Tedesco VE, Mohan C. Biomarkers for predicting cytokine release syndrome following CD19 -targeted CAR T cell therapy. J Immunol. 2021;206:1561–8.
3. Wang Z, Han W. Biomarkers of cytokine release syndrome and neurotoxicity related to CAR-T cell therapy. Biomark Res. 2018;6:4 https://doi.org/10.1186/S40364-018-0116-0.
4. Tang JP, Peters CW, Quiros C, Wang X, Klomhaus AM, Yamada RE, et al. Hypophosphatemia due to increased effector cell metabolic activity is associated with neurotoxicity symptoms in CD19-targeted CAR T-cell therapy. Cancer Immunol Res. 2022;10:1433–40.
5. Nakamura N, Arai Y, Kitawaki T, Jo T, Mizumoto C, Kanda J, et al. Decreased serum phosphate levels are a useful biomarker to predict occurrence and severity of cytokine release syndrome in chimeric antigen receptor T-cell therapy. Br J Haematol. 2023;200:e1–e3.
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1. Further modification of the EASIX score through the addition of phosphorous and IL-6 improves prediction of CRS and ICANS after CAR-T therapy;2024-07-22
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