Author:
Beck Alyssa,Lin Robert,Reza Rejali Ali,Rubens Muni,Paquette Ronald,Vescio Robert,Merin Noah,Guerrero Margarita,Federizo Yvette,Lua Michelle,Uy Leticia,Hernandez Lorraine,Allred Mohana,Legaspi Ronald,Leaverton Melissa,Oliva Sara,Castillo Rhona,Dean Lorna,Bourke Jennifer,Cooper Sara,Gharapetian Seda,Causin Jose,Lopiccolo Christopher,Ann Snoussi Laura,VanStrien Patricia,Lill Michael,Linhares Yuliya P.
Abstract
AbstractDue to the curative potential and improvement in progression-free survival (PFS), high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is considered the standard of care for several hematologic malignancies, such as multiple myeloma, and lymphomas. ASCT typically involves support with blood product transfusion. Thus, difficulties arise when Jehovah’s Witness patients refuse blood transfusions. In order to demonstrate the safety of performing “bloodless” ASCT (BL-ASCT), we performed a retrospective analysis of 66 Jehovah's Witnesses patients who underwent BL-ASCT and 1114 non-Jehovah’s Witness patients who underwent transfusion-supported ASCT (TF-ASCT) at Cedars-Sinai Medical Center between January 2000 and September 2018. Survival was compared between the two groups. Transplant-related complications, mortality, engraftment time, length of hospital stay, and number of ICU transfers were characterized for the BL-ASCT group. One year survival was found to be 87.9% for both groups (P = 0.92). In the BL-ASCT group, there was one death prior to the 30 days post transplant due to CNS hemorrhage, and one death prior to 100 days due to sepsis. Based on our data, BL-ASCT can be safely performed with appropriate supportive measures, and we encourage community oncologists to promptly refer JW patients for transplant evaluation when ASCT is indicated.
Funder
The publication of this article is generously supported by Soraya Ruben Melamed and the Melamed family of Beverly Hills
Publisher
Springer Science and Business Media LLC
Subject
Transplantation,Hematology
Cited by
6 articles.
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