A prospective pilot study of a novel alemtuzumab target concentration intervention strategy

Author:

Arnold Danielle E.,Emoto Chie,Fukuda Tsuyoshi,Dong Min,Vinks Alexander A.,Lane Adam,McIntosh Kelly,Neumeier Lisa,Lankester Arjan C.ORCID,Achini Federica,Teusink-Cross Ashley,Chandra Sharat,Jordan Michael B.,Nelson Adam S.,Myers Kasiani C.ORCID,Davies Stella M.,Mehta Parinda A.,Marsh Rebecca A.ORCID

Funder

Cincinnati Children’s Research Foundation

Publisher

Springer Science and Business Media LLC

Subject

Transplantation,Hematology

Reference9 articles.

1. Chakraverty R, Orti G, Roughton M, Shen J, Fielding A, Kottaridis P. et al. Impact of in vivo alemtuzumab dose before reduced intensity conditioning and HLA-identical sibling stem cell transplantation: pharmacokinetics, GVHD, and immune reconstitution. Blood. 2010;116:3080–8. https://doi.org/10.1182/blood-2010-05-286856.

2. Marsh RA, Kim MO, Liu C, Bellman D, Hart L, Grimley M. et al. An intermediate alemtuzumab schedule reduces the incidence of mixed chimerism following reduced-intensity conditioning hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis. Biol Blood Marrow Transpl. 2013;19:1625–31. https://doi.org/10.1016/j.bbmt.2013.09.001.

3. Gartner F, Hieke S, Finke J, Bertz H. Lowering the alemtuzumab dose in reduced intensity conditioning allogeneic hematopoietic cell transplantation is associated with a favorable early intense natural killer cell recovery. Cytotherapy. 2013;15:1237–44. https://doi.org/10.1016/j.jcyt.2013.05.016.

4. Lane JP, Evans PT, Nademi Z, Barge D, Jackson A, Hambleton S. et al. Low-dose serotherapy improves early immune reconstitution after cord blood transplantation for primary immunodeficiencies. Biol Blood Marrow Transpl. 2014;20:243–9. https://doi.org/10.1016/j.bbmt.2013.11.005.

5. Marsh RA, Lane A, Mehta PA, Neumeier L, Jodele S, Davies SM. et al. Alemtuzumab levels impact acute GVHD, mixed chimerism, and lymphocyte recovery following alemtuzumab, fludarabine, and melphalan RIC HCT. Blood. 2016;127:503–12. https://doi.org/10.1182/blood-2015-07-659672.

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