Efficient selection of genetically modified human T cells using methotrexate-resistant human dihydrofolate reductase
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,Molecular Medicine
Link
http://www.nature.com/articles/gt201297.pdf
Reference30 articles.
1. Volpato JP, Mayotte N, Fossati E, Guerrero V, Sauvageau G, Pelletier JN . Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells. J Mol Recognit 24: 188–198.
2. Milsom MD, Fairbairn LJ . Protection and selection for gene therapy in the hematopoietic system. J Gene Med 2004; 6: 133–146.
3. Riddell SR, Elliott M, Lewinsohn DA, Gilbert MJ, Wilson L, Manley SA et al. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat Med 1996; 2: 216–223.
4. Berger C, Flowers ME, Warren EH, Riddell SR . Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation. Blood 2006; 107: 2294–2302.
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