High-affinity PEGylated polyacridine peptide polyplexes mediate potent in vivo gene expression
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,Molecular Medicine
Link
http://www.nature.com/articles/gt201247.pdf
Reference39 articles.
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2. Merdan T, Kunath K, Petersen H, Bakowsky U, Voigt KH, Kopecek J et al. PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice. Bioconj Chem 2005; 16: 785–792.
3. Cohen RN, van der Aa MA, Macaraeg N, Lee AP, Szoka FC . Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection. J Cont Rel 2009; 135: 166–174.
4. Burke RS, Pun SH . Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver. Bioconj Chem 2008; 19: 693–704.
5. Grigsby C, Leong K . Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery. J Royal Soc Interface 2010; 7: S67–S82.
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